Below you will find some of our key publications. Bolded names are authors from our lab. A complete listing of our publications can be found on Pubmed.



A large-scale binding and functional map of human RNA binding proteins.

Van Nostrand EL*, Freese P*, Pratt GA*, Wang X*, Wei X*, Xiao R*, Blue SM, Dominguez D, Cody NAL, Olson S, Sundararaman B, Zhan L, Bazile C, Benoit Bouvrette LPBergalet J, Chen J, Duff MO, Garci KE, Gelboin-Burkhart C, Hochman A, Lambert NJ, Li H, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Zhou B, Su A, Wang R, Yee BA, Louie AL, Aigner S, Fu X-D¶, Lécuyer E¶, Burge CB¶, Graveley BR ¶, Yeo GW¶. * =Co-first authros; ¶ = Co-corresponding authors.

bioRXiv (doi:


Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.

Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW.

Cell. 2018, 172(3) :590-604. PMID: 29373831

CeFra-seq reveals broad asymmetric mRNA and noncoding RNA distribution profiles in Drosophila and human cells.

Benoit Bouvrette LP, Cody NAL, Bergalet J, Lefebvre FA, Diot C, Wang X, Blanchette M, Lécuyer E.

RNA. 2018, 24: 98-113. PMID: 29079635


Optimized FISH methods for visualizing RNA localization properties in Drosophila and human tissues and cultured cells.

Diot C, Chin A, Lécuyer E.

Methods. 2017, 126:156-165. PMID: 28668588

CeFra-seq: Systematic mapping of RNA subcellular distribution properties through cell fractionation coupled to deep-sequencing.

Lefebvre FA, Cody NAL, Benoît Bouvrette LP, Bergalet J, Wang X, Lécuyer E.

Methods. 2017, 126:138-148. PMID: 28579403

RNA localization: Making its way to the center stage.

Chin A, Lécuyer E.

Biochim Biophys Acta. 2017, 1861(11 Pt B):2956-2970. Review. PMID: 28630007

Biochemical Fractionation of Time-Resolved Drosophila Embryos Reveals Similar Transcriptomic Alterations in Replication Checkpoint and Histone mRNA Processing Mutants.

Lefebvre FA, Benoit Bouvrette LP, Bergalet J, Lécuyer E.

J Mol Biol. 2017, 429: 3264-3279. PMID: 28167048

Small Luggage for a Long Journey: Transfer of Vesicle-Enclosed Small RNA in Interspecies Communication.

Lefebvre FA, Lécuyer E.

Front Microbiol. 2017, 8:377.  eCollection Review. PMID: 28360889


Comparative transcriptomic analysis of human and Drosophila extracellular vesicles.

Lefebvre FA, Benoit Bouvrette LP, Perras L, Blanchet-Cohen A, Garnier D, Rak J, Lécuyer E.

Scientific Reports. 2016, 6: 27680. PMID: 27282340

Resources for the Comprehensive Discovery of Functional RNA Elements.

Sundararaman B, Zhan L, Blue SM, Stanton R, Elkins K, Olson S, Wei X, Van Nostrand EL, Pratt GA, Huelga SC, Smalec BM, Wang X, Hong EL, Davidson JM, Lécuyer E, Graveley BR, Yeo GW.

Mol Cell. 2016, 61:903-13. PMID: 26990993

Loss of function of the Drosophila Ninein-related centrosomal protein Bsg25D causes mitotic defects and impairs embryonic development.

Kowanda M, Bergalet J, Wieczorek M, Brouhard G, Lécuyer E, Lasko P.

Biol Open. 2016, 5:1040-51. PMID: 27422905


Subcellular Transcript Localization in Drosophila Embryos and Tissues Visualized by Multiplex-FISH.

Bergalet J, Iampietro C, Chin A, Oré-Rodriguez S, Nguyen X-T, Cody NA, and Lécuyer E. 2015. Edited by Giselbert Hauptmann. Neuromethods. 714: 31-47.


Developmentally regulated elimination of damaged nuclei involves a Chk2-dependent mechanism of mRNA nuclear retention.

Iampietro C, Bergalet J, Wang X, Cody NA, Chin A, Lefebvre FA, Douziech M, Krause HM, Lécuyer E.

Dev Cell. 2014, 29: 468-81. PMID: 24835465

The functions and regulatory principles of mRNA intracellular trafficking.

Bergalet J, Lécuyer E.

Adv Exp Med Biol. 2014, 825: 57-96. Review. PMID: 25201103

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.

Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang T.

PLoS Genet. 2014, 10: e1004768. PMID: 25522233

2013 and Earlier

SPARCS: a web server to analyze (un)structured regions in coding RNA sequences.

Zhang Y, Ponty Y, Blanchette M, Lécuyer E*, Waldispühl J*.

*=co-corresonding authors.

Nucleic Acids Res. 2013, 41(Web Serve r issue): W480-5. PMID: 23748952

The many functions of mRNA localization during normal development and disease: from pillar to post.

Cody NA, Iampietro C, Lécuyer E.

Wiley Interdiscip Rev Dev Biol. 2013, 2: 781-96. PMID: 24123937

Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.

Wang ET, Cody NA, Jog S, Biancolella M, Wang TT, Treacy DJ, Luo S, Schroth GP, Housman DE, Reddy S, Lécuyer E, Burge CB.

Cell. 2012, 150: 710-24. PMID: 22901804

Global implications of mRNA localization pathways in cellular organization.

Lécuyer E, Yoshida H, Krause HM.

Curr Opin Cell Biol. 2009, 21: 409-15. PMID: 19249199

Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function.

Lécuyer E, Yoshida H, Parthasarathy N, Alm C, Babak T, Cerovina T, Hughes TR, Tomancak P, Krause HM.

Cell. 2007, 131: 174-87. PMID: 17923096