L É C U Y E R L A B
R N A B I O L O G Y
P U B L I C A T I O N S
Below you will find some of our key publications. Bolded names are authors from our lab.
A complete listing of our publications can be found on Pubmed.
2025
Exploring Extracellular Vesicle Transcriptomic Diversity Through Long-Read Nanopore Sequencing
Padilla JA, Barutcu S, Deschamps-Francoeur G, Lécuyer E.
Methods Mol Biol.
2024
Canada's contributions to RNA research: past, present, and future perspectives
Lécuyer E, Sauvageau M, Kothe U, Unrau PJ, Damha MJ, Perreault J, Abou Elela S, Bayfield MA, Claycomb JM, Scott MS.
Biochem Cell Biol
(https://pubmed.ncbi.nlm.nih.gov/39320985/)
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Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation
Gosztyla ML, Zhan L, Olson S, Wei X, Naritomi J, Nguyen G, Street L, Goda GA, Cavazos FF, Schmok JC, Jain M, Uddin Syed E, Kwon E, Jin W, Kofman E, Tankka AT, Li A, Gonzalez V, Lécuyer E, Dominguez D, Jovanovic M, Graveley BR, Yeo GW.
Mol Cell
(https://pubmed.ncbi.nlm.nih.gov/39303722/)
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ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis
El Bakkouri Y, Chidiac R, Delisle C, Corriveau J, Cagnone G, Gaonac'h-Lovejoy V, Chin A, Lécuyer É, Angers S, Joyal JS, Topisirovic I, Hulea L, Dubrac A, Gratton JP.
Nat Commun
(https://pubmed.ncbi.nlm.nih.gov/38782923/)
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CircRNAome of Childhood Acute Lymphoblastic Leukemia: Deciphering Subtype-Specific Expression Profiles and Involvement in TCF3::PBX1 ALL.
Gutierrez-Camino A, Caron M, Richer C, Fuchs C, Illarregi U, Poncelet L, St-Onge P, Bataille AR, Tremblay-Dauphinais P, Lopez-Lopez E, Camos M, Ramirez-Orellana M, Astigarraga I, Lécuyer É, Bourque G, Martin-Guerrero I, Sinnett D.
Int J Mol Sci
(https://pubmed.ncbi.nlm.nih.gov/38338754/)
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PERFUMES: pipeline to extract RNA functional motifs and exposed structures
Chol A, Sarrazin-Gendron R, Lécuyer É, Blanchette M, Waldispühl J.
Bioinformatics
2023
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Profiling the polyadenylated transcriptome of extracellular vesicles with long-read nanopore sequencing
Padilla JA, Barutcu S, Malet L, Deschamps-Francoeur G, Calderon V, Kwon E, Lécuyer E.
BMC Genomics
(https://pubmed.ncbi.nlm.nih.gov/37736705/)
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RBP Image Database: A resource for the systematic characterization of the subcellular distribution properties of human RNA binding proteins
Benoit Bouvrette LP, Wang X, Boulais J, Kong J, Syed EU, Blue SM, Zhan L, Olson S, Stanton R, Wei X, Yee B, Van Nostrand EL, Fu XD, Burge CB, Graveley BR, Yeo GW, Lécuyer E.
Nucleic Acids Res
2022
Localized translation of cell junction mRNAs is required for epithelial cell polarity
Chin A, Bergeman J, Communal L, Boulais J, Mes-Masson A-M, Lécuyer E
Under review.
2021
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress.
Markmiller S, Sathe S, Server KL, Nguyen TB, Fulzele A, Cody N, Javaherian A, Broski S, Finkbeiner S, Bennett EJ, Lécuyer E, Yeo GW
Cell Reports. 2021, 36: 109685. doi: 10.1016/j.celrep.2021.109685.
(https://pubmed.ncbi.nlm.nih.gov/34496257/)
Puromycin labeling coupled with proximity ligation assays to define sites of mRNA translation in Drosophila embryos and human cells.
Chin A, Lécuyer E
Methods Mol Biol. 2021, 2381: 267-284.
(https://pubmed.ncbi.nlm.nih.gov/34590282/)
RNA interference (RNAi) screening in cultured Drosophila cells.
Padilla JA, Chin A, Patel D, Jolivet P, Lécuyer E
Methods Mol Biol. 2021, 2381: 267-284.
2020
Translating messages in different neighbouhoods.
Chin A, Lécuyer E
Dev Cell. 2020, 54: 691-693.
(https://pubmed.ncbi.nlm.nih.gov/32991835/)
A large-scale binding and functional map of human RNA-binding proteins.
Van Nostrand EL*, Freese P*, Pratt GA*, Wang X*, Wei X*, Xiao R*, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD¶, Lécuyer E¶, Burge CB¶, Graveley BR¶, Yeo GW¶
*=Co-first authors; ¶=Co-corresponding authors.
Nature. 2020, 583: 711-719.
(https://pubmed.ncbi.nlm.nih.gov/32728246/)
Expanded encyclopaedias of DNA elements in the human and mouse genomes.
ENCODE Project Consortium, Moore JE, Purcaro MJ, Pratt HE, Epstein CB, Shoresh N, Adrian J, Kawli T, Davis CA, Dobin A, Kaul R, Halow J, Van Nostrand EL, Freese P, Gorkin DU, Shen Y, He Y, Mackiewicz M, Pauli-Behn F, Williams BA, Mortazavi A, Keller CA, Zhang XO, Elhajjajy SI, Huey J, Dickel DE, Snetkova V, Wei X, Wang X, Rivera-Mulia JC, Rozowsky J, Zhang J, Chhetri SB, Zhang J, Victorsen A, White KP, Visel A, Yeo GW, Burge CB, Lécuyer E, Gilbert DM, Dekker J, Rinn J, Mendenhall EM, Ecker JR, Kellis M, Klein RJ, Noble WS, Kundaje A, Guigó R, Farnham PJ, Cherry JM, Myers RM, Ren B, Graveley BR, Gerstein MB, Pennacchio LA, Snyder MP, Bernstein BE, Wold B, Hardison RC, Gingeras TR, Stamatoyannopoulos JA, Weng Z
Nature. 2020, 583: 699-710.
(https://pubmed.ncbi.nlm.nih.gov/32728249/)
Perspectives on ENCODE.
ENCODE Project Consortium, Snyder MP, Gingeras TR, Moore JE, Weng Z, Gerstein MB, Ren B, Hardison RC, Stamatoyannopoulos JA, Graveley BR, Feingold EA, Pazin MJ, Pagan M, Gilchrist DA, Hitz BC, Cherry JM, Bernstein BE, Mendenhall EM, Zerbino DR, Frankish A, Flicek P, Myers RM
Nature. 2020, 583: 693-698.
(https://pubmed.ncbi.nlm.nih.gov/32728248/)
Staufen1 localizes to the mitotic spindle and controls the localization of RNA populations to the spindle.
Hassine S, Bonnet-Magnaval F, Benoit Bouvrette LP, Doran B, Ghram M, Bouthillette M, Lécuyer E, DesGroseillers L
J Cell Sci. 2020, 133: jcs247155. doi: 10.1242/jcs.247155.
(https://pubmed.ncbi.nlm.nih.gov/32576666/)
Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila.
Bergalet J, Patel D, Legendre F, Lapointe C, Benoit Bouvrette LP, Chin A, Blanchette M, Kwon E, Lécuyer E
Cell Rep. 2020, 30:3339-3352.
(https://pubmed.ncbi.nlm.nih.gov/32160541/)
oRNAment: a database of putative RNA binding protein target sites in the transcriptomes of model species.
Benoit Bouvrette LP, Bovaird S, Blanchette M, Lécuyer E
Nucleic Acids Res. 2020 , 48(D1):D166-D173.
2019
Bioinformatics Approaches to Gain Insights into cis-Regulatory Motifs Involved in mRNA Localization.
Benoit Bouvrette LP, Blanchette M, Lécuyer E
Adv Exp Med Biol. 2019, 1203:165-194.
(https://pubmed.ncbi.nlm.nih.gov/31811635/)
A ribosomal protein S5 isoform is essential for oogenesis and interacts with distinct RNAs in Drosophila melanogaster.
Kong J, Han H, Bergalet J, Bouvrette LPB, Hernández G, Moon NS, Vali H, Lécuyer E, Lasko P
Sci Rep. 2019, 9:13779. doi: 10.1038/s41598-019-50357-z.
(https://pubmed.ncbi.nlm.nih.gov/31551467/)
Prediction of mRNA subcellular localization using deep recurrent neural networks.
Yan Z, Lécuyer E, Blanchette M
Bioinformatics. 2019, 35:i333-i342.
(https://pubmed.ncbi.nlm.nih.gov/31510698/)
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.
Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lécuyer E, Lewcock JW, Yeo GW
Neuron. 2019, 103:802-819.
(https://pubmed.ncbi.nlm.nih.gov/31272829/)
Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription.
Xiao R, Chen JY, Liang Z, Luo D, Chen G, Lu ZJ, Chen Y, Zhou B, Li H, Du X, Yang Y, San M, Wei X, Liu W, Lécuyer E, Graveley BR, Yeo GW, Burge CB, Zhang MQ, Zhou Y, Fu XD
Cell. 2019, 178: 107-121.
2017
Diot C, Chin A, Lécuyer E.
Methods. 2017, 126:156-165. PMID: 28668588
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Lefebvre FA, Cody NAL, Benoît Bouvrette LP, Bergalet J, Wang X, Lécuyer E.
Methods. 2017, 126:138-148. PMID: 28579403
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RNA localization: Making its way to the center stage.
Chin A, Lécuyer E.
Biochim Biophys Acta. 2017, 1861(11 Pt B):2956-2970. Review. PMID: 28630007
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Lefebvre FA, Benoit Bouvrette LP, Bergalet J, Lécuyer E.
J Mol Biol. 2017, 429: 3264-3279. PMID: 28167048
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Lefebvre FA, Lécuyer E.
Front Microbiol. 2017, 8:377. eCollection Review. PMID: 28360889
2018
A large-scale binding and functional map of human RNA binding proteins.
Van Nostrand EL*, Freese P*, Pratt GA*, Wang X*, Wei X*, Xiao R*, Blue SM, Dominguez D, Cody NAL, Olson S, Sundararaman B, Zhan L, Bazile C, Benoit Bouvrette LP, Bergalet J, Chen J, Duff MO, Garci KE, Gelboin-Burkhart C, Hochman A, Lambert NJ, Li H, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Zhou B, Su A, Wang R, Yee BA, Louie AL, Aigner S, Fu X-D¶, Lécuyer E¶, Burge CB¶, Graveley BR ¶, Yeo GW¶. * =Co-first authros; ¶ = Co-corresponding authors.
bioRXiv (doi: https://doi.org/10.1101/179648).
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Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.
Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW.
Cell. 2018, 172(3) :590-604. PMID: 29373831
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Benoit Bouvrette LP, Cody NAL, Bergalet J, Lefebvre FA, Diot C, Wang X, Blanchette M, Lécuyer E.
RNA. 2018, 24: 98-113. PMID: 29079635
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Biological functions, regulatory mechanisms, and disease relevance of RNA localization pathways.
Bovaird S, Patel D, Padilla JA, Lécuyer E
FEBS Lett. 2018, 592:2948-2972.
(https://pubmed.ncbi.nlm.nih.gov/30132838/)
Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development.
Lefebvre FA, Lécuyer E
J Dev Biol. 2018, 6: 5. doi: 10.3390/jdb6010005.
(https://pubmed.ncbi.nlm.nih.gov/29615554/)
2016
Comparative transcriptomic analysis of human and Drosophila extracellular vesicles.
Lefebvre FA, Benoit Bouvrette LP, Perras L, Blanchet-Cohen A, Garnier D, Rak J, Lécuyer E.
Scientific Reports. 2016, 6: 27680. PMID: 27282340
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Resources for the Comprehensive Discovery of Functional RNA Elements.
Sundararaman B, Zhan L, Blue SM, Stanton R, Elkins K, Olson S, Wei X, Van Nostrand EL, Pratt GA, Huelga SC, Smalec BM, Wang X, Hong EL, Davidson JM, Lécuyer E, Graveley BR, Yeo GW.
Mol Cell. 2016, 61:903-13. PMID: 26990993
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Kowanda M, Bergalet J, Wieczorek M, Brouhard G, Lécuyer E, Lasko P.
Biol Open. 2016, 5:1040-51. PMID: 27422905
2015
Subcellular Transcript Localization in Drosophila Embryos and Tissues Visualized by Multiplex-FISH.
Bergalet J, Iampietro C, Chin A, Oré-Rodriguez S, Nguyen X-T, Cody NA, and Lécuyer E. 2015. Edited by Giselbert Hauptmann. Neuromethods. 714: 31-47.
2014
Iampietro C, Bergalet J, Wang X, Cody NA, Chin A, Lefebvre FA, Douziech M, Krause HM, Lécuyer E.
Dev Cell. 2014, 29: 468-81. PMID: 24835465
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The functions and regulatory principles of mRNA intracellular trafficking.
Bergalet J, Lécuyer E.
Adv Exp Med Biol. 2014, 825: 57-96. Review. PMID: 25201103
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SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.
Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang T.
PLoS Genet. 2014, 10: e1004768. PMID: 25522233
SPARCS: a web server to analyze (un)structured regions in coding RNA sequences.
Zhang Y, Ponty Y, Blanchette M, Lécuyer E*, Waldispühl J*.
*=co-corresonding authors.
Nucleic Acids Res. 2013, 41(Web Serve r issue): W480-5. PMID: 23748952
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The many functions of mRNA localization during normal development and disease: from pillar to post.
Cody NA, Iampietro C, Lécuyer E.
Wiley Interdiscip Rev Dev Biol. 2013, 2: 781-96. PMID: 24123937
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Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.
Wang ET, Cody NA, Jog S, Biancolella M, Wang TT, Treacy DJ, Luo S, Schroth GP, Housman DE, Reddy S, Lécuyer E, Burge CB.
Cell. 2012, 150: 710-24. PMID: 22901804
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Global implications of mRNA localization pathways in cellular organization.
Lécuyer E, Yoshida H, Krause HM.
Curr Opin Cell Biol. 2009, 21: 409-15. PMID: 19249199
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Lécuyer E, Yoshida H, Parthasarathy N, Alm C, Babak T, Cerovina T, Hughes TR, Tomancak P, Krause HM.
Cell. 2007, 131: 174-87. PMID: 17923096